YesO-DSR

Composition:

• Esomeprazole 40 mg
• Domperidone 30 mg (SR)

Detailed Description:

YesO DSR Capsules combine two active ingredients, Esomeprazole and Domperidone, to provide dual-action relief from gastrointestinal disorders. This formulation addresses both excessive stomach acid production and motility-related symptoms, making it a highly effective treatment for conditions such as gastroesophageal reflux disease (GERD) and dyspepsia.

Mechanism of Action:

1. Esomeprazole:

   • A proton pump inhibitor (PPI) that suppresses stomach acid secretion by inhibiting the H+/K+ ATPase enzyme system in gastric parietal cells.
   • Provides long-lasting acid suppression to promote healing and symptom relief.

2. Domperidone (SR):

   • A dopamine receptor antagonist that enhances gastric motility.
   • Improves esophageal sphincter tone and accelerates gastric emptying to reduce symptoms like nausea, vomiting, and bloating.

Indications:

YesO DSR Capsules are recommended for:

• Gastroesophageal Reflux Disease (GERD) with associated nausea or bloating.
• Acid Peptic Disorders such as hyperacidity and heartburn.
• Non-ulcer Dyspepsia.
• Gastroparesis or delayed gastric emptying.
• Prevention of gastric ulcers in patients on NSAIDs.

Benefits:

• Provides fast and sustained relief from acidity and acid reflux symptoms.
• Addresses nausea, vomiting, and bloating associated with gastric motility issues.
• Enhances patient compliance with once-daily dosing due to sustained-release formulation.

Dosage and Administration:

• Usual Dose: One capsule daily, preferably 30 minutes before a meal.
• The dose and duration should be as directed by the physician.

Storage Instructions:

• Store at room temperature, below 30°C.
• Keep away from moisture and direct sunlight.
• Keep out of reach of children.

Precautions:

• Not suitable for patients with known hypersensitivity to Esomeprazole or Domperidone.
• Use with caution in patients with:
  • Liver or kidney dysfunction.
  • Prolonged QT interval or electrolyte imbalances.
• Avoid alcohol consumption during treatment.
• Not recommended for long-term use without medical supervision.

Side Effects:

• Common: Headache, diarrhea, dry mouth, dizziness.
• Less Common: Abdominal discomfort, flatulence, fatigue.
• Rare but Serious:
  • Severe allergic reactions (rash, swelling, difficulty breathing).
  • QT prolongation leading to arrhythmias.
  • Low magnesium levels (with long-term use).