Ulzero

Composition:

• Pantoprazole 40 mg (W.F.I.)

Description:

Ulzero Vial is a sterile solution containing Pantoprazole, a proton pump inhibitor (PPI). It works by reducing the production of stomach acid, making it highly effective in the treatment of acid-related gastrointestinal disorders. This injectable form of Pantoprazole is ideal for patients who cannot take oral medication due to nausea, vomiting, or other conditions.

Indications:

Ulzero Vial is used in the treatment of:

• Gastroesophageal Reflux Disease (GERD):
  • To heal erosive esophagitis and reduce symptoms of acid reflux.
• Peptic Ulcer Disease:
  • Treats and prevents ulcers in the stomach and duodenum caused by excess acid production.
• Zollinger-Ellison Syndrome:
  • A condition causing excessive acid production in the stomach.
• H. pylori Eradication:
  • Used as part of combination therapy for eradicating Helicobacter pylori infections associated with ulcers.
• Prevention of Stress Ulcers:
  • Prevents the formation of stress-related ulcers, particularly in critically ill patients.

Benefits:

• Fast-acting: Injectable form allows rapid relief from acid-related disorders, especially when oral administration is not an option.
• Effective in Gastric Ulcers: Helps heal ulcers by reducing stomach acid secretion, promoting healing of the mucosal lining.
• Proven Therapy for GERD: Significantly reduces heartburn and regurgitation symptoms in GERD patients.
• Prevention of Gastric Bleeding: Reduces the risk of gastrointestinal bleeding in critically ill patients.

Dosage and Administration:

• Usual Adult Dose:
  • 40 mg (one vial) once daily, administered by intravenous injection over at least 2-3 minutes.
• Duration: Treatment duration depends on the condition being treated.
  • GERD and peptic ulcer healing typically require 7-14 days.
  • Zollinger-Ellison syndrome may require longer treatment periods.
• H. pylori eradication: Combined with antibiotics as part of a treatment regimen for ulcers.
• Administration:
  • For intravenous use only.
  • Administer slowly to avoid adverse effects.

Storage Instructions:

• Store in a cool, dry place at room temperature (below 25°C).
• Keep the vial in its original packaging to protect from light.
• Keep out of reach of children.

Precautions:

• Allergy: Not suitable for individuals with hypersensitivity to Pantoprazole or any other PPIs.
• Liver Disease: Use with caution in patients with liver impairment. Dose adjustments may be necessary.
• Long-term Use: Extended use may increase the risk of bone fractures, vitamin B12 deficiency, and Clostridium difficile-associated diarrhea.
• Drug Interactions:
  • May interact with drugs like warfarin, methotrexate, and certain antifungal agents.
  • Consult your doctor about potential interactions with other medications.
• Pregnancy and Lactation: Use only if clearly needed. Pantoprazole is excreted in breast milk, and its use should be discussed with a healthcare provider.

Side Effects:

• Common:
  • Headache, nausea, diarrhea, abdominal pain, dizziness.
• Serious:
  • Severe allergic reactions, liver dysfunction (jaundice), and low magnesium levels.
  • Long-term use can lead to bone fractures, kidney problems, and vitamin B12 deficiency.

Key Notes:

• Not for Long-Term Use: Should be used for the shortest duration necessary to manage symptoms.
• Consult Your Healthcare Provider: If you experience any adverse effects or if the treatment is not effective.
• Do Not Skip Doses: Ensure you receive your dose on time for effective treatment.