KefiZone-1.5-S

Composition:

• Cefoperazone 1000 mg
• Sulbactam 500 mg
• With Water for Injection (W.F.I.)

KefiZone 1.5 S is a combination of Cefoperazone, a third-generation cephalosporin antibiotic, and Sulbactam, a β-lactamase inhibitor. This combination enhances antibacterial efficacy by overcoming resistance mechanisms in β-lactamase-producing bacteria. It is designed for the treatment of severe bacterial infections caused by multidrug-resistant pathogens.

Indications:

KefiZone 1.5 S is used in the treatment of a wide range of serious bacterial infections, including:

1. Respiratory Tract Infections: Pneumonia, bronchitis.
2. Urinary Tract Infections (UTIs): Complicated and recurrent infections.
3. Intra-Abdominal Infections: Peritonitis, cholangitis.
4. Septicemia: Bloodstream infections.
5. Skin and Soft Tissue Infections: Cellulitis, abscesses, diabetic foot infections.
6. Bone and Joint Infections: Osteomyelitis, septic arthritis.
7. Gynecological Infections: Pelvic inflammatory disease, endometritis.
8. Surgical Prophylaxis: Prevents infections during and after surgery.

Benefits:

1. Enhanced Activity: Sulbactam protects Cefoperazone from degradation by β-lactamase enzymes, extending its spectrum of action.
2. Broad Spectrum: Effective against gram-positive, gram-negative, and anaerobic bacteria.
3. Dual Mechanism: Combines bactericidal action (Cefoperazone) with enzyme inhibition (Sulbactam) for optimal efficacy.

Dosage and Administration:

• Route: Intravenous (IV) or Intramuscular (IM) injection.
• Typical Dosage:
  • Adults: 1.5 g every 12 hours (adjustable based on infection severity and patient condition).
  • Dosage for pediatric patients should be determined by the physician.
• Preparation: Reconstitute the vial using the provided Water for Injection (W.F.I.) or as per instructions by the healthcare provider.

Storage Instructions:

• Store below 25°C, protected from light and moisture.
• Use the prepared solution immediately to avoid contamination.
• Keep out of reach of children.

Precautions:

1. Allergies: Contraindicated in patients with known allergies to cephalosporins or penicillins.
2. Renal and Hepatic Impairment: Adjust dosage under medical supervision for patients with kidney or liver dysfunction.
3. Bleeding Disorders: Use cautiously, as Cefoperazone may affect coagulation.
4. Pregnancy and Lactation: Consult a healthcare professional before use.
5. Drug Interactions:
   • Avoid alcohol during treatment and for 72 hours after the last dose, as it may cause disulfiram-like reactions.
   • Inform the doctor of concurrent medications to prevent interactions.

Side Effects:

• Common: Nausea, vomiting, diarrhea, pain at the injection site.
• Less Common: Allergic reactions (rash, itching, swelling), headache, fever.
• Rare: Blood disorders, severe hypersensitivity reactions, pseudomembranous colitis (seek immediate medical attention).

Note:

KefiZone 1.5 S is a prescription medication administered under the supervision of healthcare professionals. Adherence to the prescribed dosage and schedule is crucial to ensure its effectiveness and reduce the risk of resistance.