Valex-CR-300

Composition:

• Sodium Valproate 200 mg
• Valproic Acid 87 mg

Description:

Valex CR 300 is a combination medication containing Sodium Valproate and Valproic Acid, primarily used to manage seizures in individuals with epilepsy, as well as to treat mood disorders such as bipolar disorder. It helps in stabilizing electrical activity in the brain, preventing the occurrence of seizures and episodes of extreme mood swings.

The medication comes in extended-release tablets (CR), designed to maintain a steady level of the drug in the bloodstream over time, allowing for effective management of conditions without frequent dosing. It provides convenience and enhances patient compliance by reducing the number of doses required throughout the day.

Indications:

Valex CR 300 is indicated for the treatment of:

• Epilepsy: Used in the management of generalized and partial seizures in adults and children.
• Bipolar Disorder: Helps in the stabilization of mood swings, including the treatment of acute manic episodes and long-term maintenance.
• Migraine Prophylaxis: May be used to reduce the frequency and severity of migraines.
• Neuropathic Pain: In certain cases, Valex CR may be used off-label for managing chronic pain conditions associated with nerve damage.

Benefits:

• Extended-Release: Provides controlled release, minimizing fluctuations in drug levels.
• Dual Action: Combines Sodium Valproate and Valproic Acid for effective treatment of both seizures and mood disorders.
• Versatile: Can be used in both epilepsy and bipolar disorder management.
• Reduces Seizure Frequency: Effective in preventing both generalized and partial seizures.
• Mood Stabilizing: A valuable treatment option for patients with bipolar disorder, reducing the occurrence of manic episodes.

Dosage and Administration:

• Adult Dosage:
  • Epilepsy: 600 mg to 1200 mg daily, divided into 2-3 doses.
  • Bipolar Disorder: Typically started at 600 mg daily, with gradual adjustments based on response.
• Children: Dosage is based on body weight and should be prescribed by a healthcare provider.
• Take with food: Helps minimize gastrointestinal side effects.
• Do not crush or chew: Swallow whole for optimal extended-release effect.

Storage Instructions:

• Store at room temperature, between 20°C to 25°C (68°F to 77°F).
• Keep in a tightly closed container to protect from moisture.
• Keep out of reach of children.

Precautions:

• Liver Function: Monitor liver function regularly, as Valproate may cause hepatotoxicity.
• Pregnancy: Should be avoided during pregnancy unless absolutely necessary, as it may cause birth defects. Discuss with your doctor if pregnant or planning to become pregnant.
• Alcohol: Avoid alcohol as it can enhance the sedative effects and increase the risk of liver damage.
• Kidney and Pancreatic Issues: Use with caution if you have a history of kidney disease or pancreatitis.
• Interaction with Other Medications: Inform your doctor if you are on other medications, particularly those affecting liver enzymes, anticoagulants, or other anti-epileptic drugs.
• Discontinuation: Gradual reduction is recommended to prevent withdrawal seizures.

Side Effects:

• Common Side Effects:
  • Nausea, vomiting, dizziness, drowsiness, weight gain.
  • Mild tremors or shaking.
  • Headache, fatigue, or abdominal discomfort.
• Serious Side Effects:
  • Severe liver damage (jaundice, abdominal pain, unusual fatigue).
  • Pancreatitis: Sudden severe abdominal pain, nausea, and vomiting.
  • Teratogenic Effects: Use caution in women of childbearing age.
  • Blood disorders such as thrombocytopenia or leukopenia.

Key Notes:

• Regular Monitoring: Liver and kidney functions should be regularly monitored during treatment.
• Patient Compliance: Follow the prescribed dosage schedule for optimal effectiveness.
• Consult a Healthcare Provider: Always consult your doctor for dosage adjustments or if side effects persist.