Valex-CR-500

Composition:

• Sodium Valproate 333 mg
• Valproic Acid 145 mg

Description:

Valex CR 500 is a combination of Sodium Valproate and Valproic Acid formulated as a controlled-release (CR) tablet. This dual-action medication is primarily used for managing epilepsy and bipolar disorder. It works by stabilizing neuronal activity in the brain, reducing the occurrence of seizures and mood swings.

Indications:

Valex CR 500 is indicated for:

1. Epilepsy:
   • Treatment of generalized seizures such as tonic-clonic, myoclonic, and absence seizures.
   • Management of focal seizures.
2. Bipolar Disorder:
   • Used as a mood stabilizer to control manic episodes.
3. Migraine Prophylaxis:
   • Prevents the onset of chronic migraines.

Mechanism of Action:

The active components of Valex CR work synergistically to enhance the inhibitory neurotransmitter GABA (gamma-aminobutyric acid) in the brain. This action:

• Stabilizes overactive nerve signals, preventing seizures.
• Balances mood swings in bipolar disorder.

Key Benefits:

• Controlled-Release Formula: Ensures sustained therapeutic levels in the bloodstream for extended relief.
• Broad Spectrum: Effective against multiple types of seizures.
• Dual Role: Treats both neurological and psychiatric conditions.

Dosage and Administration:

• Adults and Children (above 10 years): Usually 500 mg to 1000 mg daily, adjusted based on the condition and response.
• To be taken with food to reduce gastrointestinal irritation.
• Do not crush or chew the tablet; swallow it whole.

Storage Instructions:

• Store below 30°C in a dry place.
• Protect from direct sunlight and moisture.
• Keep out of reach of children.

Precautions:

• Liver Function: Monitor liver enzymes periodically as valproate can cause hepatic dysfunction.
• Pregnancy: Avoid during pregnancy unless essential, as it may lead to birth defects.
• Drug Interactions: Inform your doctor about all medications being taken, especially:
  • Anticoagulants.
  • Other anticonvulsants.
  • Alcohol (can amplify side effects).
• Caution:
  • May cause drowsiness; avoid driving or operating heavy machinery.
  • Regular blood tests may be required to monitor valproate levels.

Side Effects:

• Common:
  • Nausea, vomiting, stomach pain, weight changes, drowsiness, and tremors.
• Rare but Serious:
  • Liver toxicity, pancreatitis, hair loss, thrombocytopenia (reduced blood platelets).
• Neurological:
  • Headaches, dizziness, or confusion.