Ulzero D

Composition:

• Pantoprazole 40 mg
• Domperidone 10 mg

Description:

Ulzero D is a combination medication containing Pantoprazole and Domperidone, designed to effectively manage gastroesophageal reflux disease (GERD), gastritis, and functional dyspepsia. This dual-action formula helps reduce stomach acid production and alleviates nausea, vomiting, and bloating, providing comprehensive relief from digestive discomfort.

Mechanism of Action:

1. Pantoprazole (40 mg):

   • A proton pump inhibitor (PPI) that works by inhibiting the proton pumps in the stomach lining, reducing the production of stomach acid.
   • Pantoprazole effectively treats conditions like GERD, peptic ulcers, and Zollinger-Ellison syndrome.

2. Domperidone (10 mg):

   • A dopamine antagonist that works to improve motility in the stomach and intestines.
   • It relieves nausea and vomiting by blocking dopamine receptors in the upper gastrointestinal tract.

Indications:

Ulzero D is indicated for:

• Gastroesophageal reflux disease (GERD): Alleviates symptoms like heartburn, acid reflux, and regurgitation.
• Functional dyspepsia: Relieves bloating, early satiety, and discomfort due to indigestion.
• Gastroparesis and nausea: Helps manage delayed gastric emptying and associated symptoms.
• Peptic ulcers: Aids in ulcer healing and preventing ulcer recurrence.

Benefits:

• Dual-Action Relief: Pantoprazole reduces acid secretion, while Domperidone enhances gastric motility and controls nausea.
• Faster Recovery: Combined action provides faster relief from discomfort and improves digestion.
• Convenience: Single tablet formulation, reducing the need for multiple medications.
• Reduced Gastric Irritation: Pantoprazole helps heal damaged tissues in the stomach lining and esophagus, while Domperidone eases symptoms like nausea.

Dosage and Administration:

• Adults: Typically, one tablet (40 mg Pantoprazole + 10 mg Domperidone) taken once daily, preferably before a meal.
• Duration: The duration of treatment depends on the condition and response to therapy. Follow the doctor's instructions carefully.
• Swallow the tablet whole with a glass of water; do not chew or crush it.

Storage Instructions:

• Store at room temperature (below 25°C).
• Keep in a dry place away from moisture and direct sunlight.
• Keep out of the reach of children.

Precautions:

• Pregnancy & Lactation: Consult a doctor before using if pregnant or breastfeeding.
• Liver or Kidney Disease: Use with caution in patients with liver or kidney disorders.
• Drug Interactions: May interact with certain medications, including:
  • Antifungals: Ketoconazole, itraconazole.
  • Antibiotics: Rifampicin, clarithromycin.
  • Anticoagulants: Warfarin, which may increase bleeding risk.
• Long-term use: Prolonged use of PPIs like Pantoprazole may lead to low magnesium levels and an increased risk of fractures.

Side Effects:

• Common:
  • Diarrhea, headache, nausea, dry mouth, abdominal discomfort.
• Uncommon but Serious:
  • Allergic reactions such as rashes, swelling, or difficulty breathing.
  • Severe dizziness or lightheadedness.
  • Liver enzyme abnormalities (in rare cases).
  • Long-term use may increase the risk of vitamin B12 deficiency.

Key Notes:

• Do not stop treatment abruptly without consulting a doctor.
• Ulzero D should be used as part of a comprehensive treatment plan that includes dietary changes and lifestyle adjustments.
• Consult your doctor if symptoms do not improve after a few weeks of treatment.