VoriCan-200

Composition:

• Voriconazole 200 mg

Description:

VoriCan 200 contains Voriconazole, a broad-spectrum triazole antifungal medication. It is primarily used for treating serious fungal infections, particularly in immunocompromised patients. Voriconazole inhibits fungal growth by interfering with ergosterol synthesis, an essential component of fungal cell membranes.

Indications:

VoriCan 200 is effective against:

1. Invasive Aspergillosis
   • A severe fungal infection affecting the lungs, brain, or other organs.
2. Esophageal Candidiasis
   • Infection caused by Candida species in the esophagus.
3. Candidemia
   • Bloodstream infections caused by Candida species.
4. Fusariosis and Scedosporiosis
   • Rare, difficult-to-treat fungal infections.
5. Empiric Antifungal Therapy
   • For febrile neutropenic patients with suspected fungal infections.

Benefits:

• Highly effective against a wide range of fungal pathogens.
• Penetrates tissues and the central nervous system, making it suitable for invasive infections.
• Superior efficacy compared to older antifungals in certain infections like aspergillosis.

Dosage and Administration:

• Adults:
  • Recommended starting dose: 400 mg every 12 hours for the first day (loading dose).
  • Maintenance dose: 200 mg every 12 hours.
  • Dosage adjustments may be necessary for liver impairment or drug interactions.
• Administration:
  • Take on an empty stomach (at least 1 hour before or 1 hour after meals).

Storage Instructions:

• Store below 30°C.
• Keep in a cool, dry place, away from direct sunlight.
• Keep out of reach of children.

Precautions:

• Allergy: Avoid use in patients with hypersensitivity to voriconazole or other azole antifungals.
• Drug Interactions: Voriconazole interacts with multiple drugs, such as:
  • Rifampin, carbamazepine (reduced voriconazole levels).
  • Cyclosporine, tacrolimus (increased levels of these drugs).
  • Statins and anticoagulants (monitor for toxicity).
• Liver and Kidney Function: Regular monitoring is required for patients with hepatic or renal impairment.
• Avoid in pregnant or breastfeeding women unless absolutely necessary.

Side Effects:

• Common:
  • Visual disturbances (blurred vision, sensitivity to light).
  • Nausea, vomiting, diarrhea.
  • Headache, rash.
• Less Common:
  • Liver enzyme elevation.
  • Skin reactions (photosensitivity).
• Rare but Serious:
  • Severe allergic reactions.
  • QT prolongation leading to arrhythmias.
  • Hepatotoxicity.

Key Notes:

• Vorican 200 is a highly effective antifungal option for treating invasive and life-threatening fungal infections.
• Complete the prescribed treatment course to ensure the infection is eradicated.
• Monitor for side effects, especially if on other medications or with pre-existing conditions.

This medication is an essential component of antifungal therapy, providing relief and recovery in severe fungal infections.